Thereafter, his consciousness level improved, and his respiratory condition gradually stabilized; therefore, he was extubated on the 55th hospital day. Material and methods Cases of organophosphorus poisoning presented to SN Medical college, Agra between the period from January 2011 to December 2016 were included in this study. Organophosphates are a common class of insecticides. presenting in a critical condition to tertiary level hospitals. Organophosphorus pesticide (OPPs) is a class of substances frequently encountered in surface water and groundwater coming from agro-industrial processes. 1. A case-control study was therefore initiated to evaluate in-depth factors responsible for the incidence of acute organophosphorus poisoning cases and to determine the intention of poisoning, the socioeconomic status of victims, the precipitating factors, the clinical and biochemical alterations, and finally the outcome of the treatment of patients admitted to the local civil hospital. 2000 Apr. The police reported that he may have ingested an organophosphorus pesticide according to the information on the empty bottle found nearby the patient. Ikezaki T: Wrote the course of treatment and designed figures. Materials: A total of 185 patients with organophosphorus compound poisoning admitted to the hospital during the study period, out of which 62 were included in the study. 2. There is an urgent need to address this issue and take measures to control the widespread availability and usage. MATERIALS AND METHODS: This retrospective study evaluated the hospital records of patients with acute OP poisoning. 2015 Jun;7(6):259-65. doi: 10.4103/1947-2714.159331. The loss of lives due to these infections is huge. Several studies reported the problem of fake antimalarial drugs in the past. Since his blood Hb level was slightly reduced, the patient received intermittent blood transfusions on an almost daily basis until the 27th hospital day. The huge market of counterfeit drugs supplying the fake antimalarial drugs, particularly artisunate is flourishing. In this study, spontaneous respiration level became low 25 hours after ingestion. While at home, the patient suddenly developed headache, dizziness, weakness, nausea, vomiting, and diarrhea. constitutes the plagiarism. Singh G, Sidhu UP, Mahajan R, et al. Guanitoxin is a naturally occurring organophosphate produced by cyanobacteria.. Aso S, Ehara H, Anai M, et al (1999) Effects on growth of rat offspring born from dams treated subcutaneously with a surfactant, polyoxyethylene (10) nonylphenyl ether (NP-10), during lactational period. Organophosphorus Poisoning Case Study 1526 Words | 7 Pages. It can rarely affect other organ systems but when it does, it can worsen a patient's overall prognosis. We conjecture that the patient acquired more severe toxicity because he lay supine on the bed for a long time; therefore, gravity and the morphological formation of the colon allowed organophosphorus pesticide to accumulate in the SDJ. Ultimately, bilateral peroneal paralysis, which appears to be a sequela to organophosphate-induced neuropathy, remained; however, he was discharged on the 122nd hospital day after rehabilitation. Materials and Methods: The present 1-year hospital-based longitudinal study was done on a total of 85 patients admitted with OP compound poisoning in the Department of Medicine, Hospital and Medical Research Centre, from January 2014 to December 2014. A study of clinical profile of patients with organophosphorus poisoning. information centers will help to curtail this public health problem. A further search of relevant literature revealed that the organophosphorus pesticide in question contains approximately 30% methanol and 5-10% polyoxyethylene nonylphenyl ether (NPE)3. Accidental poisoning ratio far less but is also a dilemma in places where highly toxic organophosphorus pesticides are available. Foundation for Combating Malnutrition in India. The majority of patients give a history of intentional or accidental ingestion of organophosphorus compounds. © 2008-2021 ResearchGate GmbH. Thirty minutes after being admitted, he was able to nod when spoken to, and was able to answer questions by shaking his head after 2.5 hours. 66, No. ... Pralidoxime (a specific cholinesterase reactivator) should also be started within four hours of exposure [11]. Organophosphates are used as insecticides, medications, and nerve agents. In this case control study, ... Changes in human plasma lipid peroxidation following acute organophosphorus insecticide poisoning. Tanaka M, Takeuchi M, Yamatani K, Ohkubo J, Handa A and Nitta A: Edited the article and contributed to the quality of the discussion. Age-related hearing loss (ARHL), or presbycusis, is a complex degenerative sickness that influences a huge number of elderly individuals all through the world.ARHL leads to bilaterally symmetrical hearing loss resulting from the aging process. However, a considerable amount of time had passed since the ingestion of the pesticide; therefore, we decided to administer symptomatic treatment only and perform a follow-up observation. Male were more affected then female. It is important to study the causes of bleeding in the present case. Organophosphorus poisoning: A case report with review of literature. Although melena subsided 2 months after admission, colonoscopy revealed severe stenosis and passage disturbance in the colon, for which he underwent partial colectomy, and was ultimately discharged. Results: Out of the 67 patients admitted to the ICU during the study 151 april 2008, Vol. The world has suffered the pandemics due to swine flu in the past. Onodera K, Yokota H, Kato K et al. high APACHE II and SOFA scores (p =0.0001 and p=0.006, Furthermore, we observed an aggravation of state of consciousness again on the 15th hospital day, which indicated the cause by gastrointestinal bleeding appeared immediately after the day, anemia, and MRSA pneumonia. A Clinico-Epidemiological Study of Organophosphorus Poisoning at a Rural-Based Teaching Hospital in Eastern Nepal Prahlad Karki, MD , Samuel George Hansdak, MD , Sangita Bhandari, MBBS , Ashutosh Shukla, MD , and Shekhar Koirala, MD c. Mucosal epithelium had regenerated, but incompletely in the glandular body (HE, ×100). AddressDepartment of Medical Oncology Toyama University Hospital 2630 Sugitani, Toyama-shi, Toyama pref., 930-0194, Japan Previous studies have indicated the possibility that, because the orally administered organophosphorus pesticide becomes pultaceous on the gastrointestinal wall and dissolves gradually, it causes the late development of symptoms and their chronicity18. doi:10.14340/spp.2013.12C0006. mortality rate of 35%. Such spreading agents include NPE and polyoxyethylene octylphenyl ether (OPE). highlights the important points associated with this campaign and are extracted from the HIFA Quotations Study duration: December 2010 – October 2011. In conclusion, delayed-onset lower gastrointestinal bleeding was suspected, and could not be excluded of having been caused by the ingested organophosphorus pesticide and spreading agent as an additive; therefore, when managing organophosphorus poisoning, attention should also be focused on the presence or absence of spreading agents such as NPE, and identifying the ingredients of the pesticide as soon as possible. 1. Eighty per cent of poisoning events were accidental in … The present situation in the sub-Saharan Africa and South East Asia due to malaria is gruesome. atropine and drugs that regenerate the cholinesterase enzyme i.e. Hence the present stud\ud y is\ud undertaken to assess severity of poisoning, management and outcome of organophosphorous\ud poisoning cases admitted in Government General Hospital, Kakinada, A. 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