ethylene glycol monobutyl ether health effects

… This can cause anemia. Substance name : Glycol Ether EB CAS-No. In both the ethylene and diethylene glycol series, the relative rate of absorption declined from methyl to ethyl to butyl ether derivatives. It is miscible in water, alcohol, ether, acetone, and ethylene glycol… Miller RR, Hermann EA, Young JT, Landry TD, Calhoun LL. The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Ethylene Glycol Monoethyl Ether (110-80-5) LD50 oral rat 1746 mg/kg LD50 dermal rabbit … CAS-Number. Respiratory Effects: Inhaled ethylene glycol can irritate the respiratory tract. 1995;69(8):526-32. doi: 10.1007/s002040050207. Opinion on Ethylene glycol monobutyl ether _____ 7 3.1.9. 1984 Aug;57:47-68. doi: 10.1289/ehp.845747. Throat and upper respiratory irritation were the most common complaints following prolonged experimental exposures in humans (4 weeks at concentrations of 1-25 ppm). 4.3. Comparative acute and subchronic toxicity of ethylene glycol monopropyl ether and ethylene glycol monopropyl ether acetate. 57, pp. Find Lowest Prices. Would you like email updates of new search results? Transient non-cardiogenic pulmonary edema following massive ingestion of ethylene glycol butyl ether. Read More. Effects of short-term exposure The substance is irritating to the eyes, skin and respiratory tract. ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE is incompatible with the following: Oxidizers (NIOSH, 2016). Read More. Ethylene … Cohen, R. (1984) Reversible subacute ethylene glycol monomethyl ether toxicity associated with microfilm production, a … USA.gov. Information available on … 2-Butoxyethanol (bu-tox-zi-eth-an-ol) has many names, including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellosolve, butyl glycol, ... if they do, what the type and severity of these health effects … A 2010 EPA re-evaluation found that ethylene glycol monobutyl ether is not likely to be carcinogenic to humans for exposures at or below reference concentrations or doses and in the absence of critical noncancer effects… Teratologic evaluation of ethylene glycol monobutyl ether in Fischer 344 rats and New Zealand white rabbits following inhalation exposure. It is an ether-ester derivative. Int Arch Occup Environ Health. -, Toxicol Appl Pharmacol. 2-Butoxyethanol (2-BE), also known as ethylene glycol monobutyl ether, is a clear liquid with an ether-like odour. | Histopathological effects consisted of excessive extramedullary splenic hematopoiesis, renal tubular degeneration, hemosiderin deposition in the spleen and kidney and accumulation in Kupffer cells, and … -. Summary: 2-Butoxyethanol is a clear colorless liquid that smells like ether. The ether being relatively unreactive. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. 2-Methoxyethanol (McGregor et al., 1983), ethylene glycol monobutyl ether (Tyler, 1982), dlethylene glycol monobutyl ether (Thompson et al., 1984), dlethylene glycol dimethyl ether (McGregor et al., 1983), propylene glycol methyl ether {Mendrala, 1983c), and dlpropylene glycol methyl ether (Mendrala, 1983b) were negative 1n the cell culture test for unscheduled DNA synthesis. FIRST AID MEASURES First aid measures Eye contact Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. ETHYLENE OXIDE Causes reproductive effects . 1. Effects observed in humans included nasal and … Ethylene Glycol 107-21-1 Hazard Summary Ethylene glycol has many uses, including as antifreeze in cooling and heating systems, in hydraulic brake fluids, and as a solvent. 111-76-2], considering butoxyacetic acid in urine to characterise the internal exposure. 2017 Jul 27;59(4):364-366. doi: 10.1539/joh.17-0148-OP. Environ Health Perspect. It attacks some forms of plastics, rubber and coatings. Health Effects Division (7509C) Pauline Wagner, Chief Inert Ingredient Assessment Branch (IIAB) Registration Division (7505C) BACKGROUND Attached is the science assessment for one exemption from the requirement of a tolerance for ethylene glycol monobutyl ether (EGBE). No harmful effects were seen on their lungs or hearts. This substance ranges from B to C depending on concentration/usage. Workers may be harmed from exposure to 2-butoxyethanol. 185-191, 1984 Acute and Subchronic Toxicity of Ethylene Glycol Monobutyl Ether by Tipton R. Tyler* The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. DIETHYLEN Glycol M-ETHYL ETHER Liquid. Diethylene Glycol Poisoning Precautions. Inhalation: Toxic ifinhaled. The main systemic adverse effects of 2-butoxyethanol are on the haematopoietic system (haemolytic effects), followed by possible teratogenic and testicular effects. -, Sangyo Igaku. 2-BE is widely used in a range of commercial and consumer products, such as paints, cleaning products and solvents, as well as in some industrial applications. O-butyl ethylene glycol butyl glycol EGBE ethylene glycol n-butyl ether glycol butyl ether monobutyl glycol ether 3-oxa-1-hepatanol Chemical name (CAS) 2-butoxyethanol CAS number 111-76-2 Since the MAK documentation from 1983 and 1986 (“2-Butoxyethanol”, Volume 6, Diethylene glycol (DEG) is an organic compound with the formula (HOCH 2 CH 2) 2 O. 2017 Jul 27;59(4):364-366. doi: 10.1539/joh.17-0148-OP. 4 Fukushima Medical University. 4 Fukushima Medical University. Acute (short-term) exposure of humans to ethylene glycol by ingesting large quantities causes three stages of health effects… Epub 2017 Jun 26. Nagano K, Nakayama E, Oobayashi H, Nishizawa T, Okuda H, Yamazaki K. Environ Health Perspect. I.A. 2-Butoxyethanol (ethylene glycol monobutyl ether): Target Organs and Levels of Evidence for TR-484 Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) This site needs JavaScript to work properly. (1993) Technical report on toxicity studies of ethylene glycol ethers 2-methoxyethanol, 2-ethoxyethanol, 2-butoxyethanol administered in drinking water to F344/N rats and B6C3F1 mice. | Most important symptoms and effects, both acute and delayed Symptoms/effects after inhalation : Harmful if inhaled. For this reason, some items on this page will be unavailable. Substance Name — Ethylene glycol monobutyl ether (EGBE) CASRN — 111-76-2 Last Revised — 3/31/2010 . It is also known as ethylene glycol monobutyl ether acetate, butoxyethyl acetate, butyl glycol acetate, ethylene glycol butyl ether acetate, and acetic acid 2-butoxyethyl ester. 1987 Nov;91(2):222-34. tration. 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). 1992;18(4):250-1. doi: 10.1007/BF01709843. Please contact NTP, IARC, or EPAâs IRIS Hotline with questions on cancer and cancer classification. Animal studies have reported reproductive and developmental risks from inhalation … In view of recent findings with other chemically related glycol ethers, particular attention has been given to possible adverse effects on blood and testicular tissue. 2006;25 Suppl 2:121-38. doi: 10.1080/10915810600964642. 0.03ppm; P=0.017). Vapors irritate eyes and nose. 1977 May 26;267(5609):335 3 Independent Consultant. 2-BE itself is not commercially produced in Canada. The information in this MRL serves as a screening tool to help public health professionals decide where to look more closely to evaluate possible risk of adverse health effects from human exposure. In evaluating the hazard that this chemical … A U.S. … Chronic exposure in humans is associated with neurological and blood effects, such as nausea, tremor, and anemia. 1984 Aug;57:75-84. doi: 10.1289/ehp.845775. NIH 1974 Feb;27(2):342-54 Symptoms may include tiredness, … Chemical Name. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health… SUBJECT: Reassessment of Tolerance Exemptions for Ethylene Glycol, Diethylene Glycol, Diethylene Glycol Monomethyl Ether, Diethylene Glycol Monoethyl Ether, and Diethylene Glycol Monobutyl Ether FROM: Kit Farwell, D.V.M. 2-Butoxyethanol is a clear colorless liquid that smells like ether. NIOSH Criteria for a Recommended Standard. Reference Dose (RfD) for Chronic Oral Exposure . It is also used in liquid soaps, cosmetics, industrial and household cleaners, and dry-cleaning compounds. ICSC Routes of Exposure and Symptoms. 1984 Aug;57:233-9. doi: 10.1289/ehp.8457233. Ethylene Glycol Ethers Group - information sheet - Canada.ca 2-Butoxyethanol was classified in : 111-76-2 Formula : C6H14O2 Synonyms : 2-butoxyethanol / BGE / butyl cellosolve / butyl OXITOL / butylglycol / butylglycol ether / EGBE / ethanol, 2-butoxy- / ethyleenglycolmonobutylether / ethylene glycol monobutyl ether / glycolmonobutylether / monobutyl ether … 1970 Jan;27(1):1-18 FIRST AID MEASURES First aid measures Eye contact Rinse … Diethylene glycol ethers were absorbed more slowly than the corresponding ethylene glycol ethers. The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure. Aspects of biological monitoring of exposure to glycol ethers. During 2003, the production of EGBE in the European Union was approximately 161,000 tonnes. Exposure to 60 ppm aerosolized ethylene glycol caused very noticeable irritation. The substance may cause effects on the central nervous system, blood, kidneys and liver. Ethylene Glycol Monobutyl Ether 111-76-2 <25 * *The exact percentage (concentration) of composition has been withheld as a trade secret. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Cincinnati, OH, US Department of Health and Human Services, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 1990. Print Share on: Evidence. The ratings reflect potential health … -, Toxicol Appl Pharmacol. Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE) (CAS No. It is also used in some ink and spot remover compounds. Studies on EGM using hamsters or guinea pigs revealed the occurrence of testicular atrophy similar to that observed in mice. DIPROPYLENE GLYCOL BUTYL ETHER can be found in 39 products. I. EPA/635/R-08/006F. Diethylene glycol (DEG) is an organic compound with the formula (HOCH 2 CH 2) 2 O. (ethylene glycol monobutyl ether) [CAS No. Function and uses EGBE belongs to the group of glycol ethers, which are mainly used as solvents. In humans, 100 ppm (69 mg/kg bw/day) resulted in ocular and respiratory Irritation, altered taste and nausea (Carpenter et al., 1956). REACH regulation aims to improve the protection of human health and the environment from the risks that can be ... new labelling, classification or hazard statement, neither reflect other factors that affect the susceptibility of the effects ... 2-butoxyethanol ethylene glycol monobutyl ether butyl cellosolve . Summary about a hazardous substance taken from Chapter One of its respective ATSDR Toxicological Profile. " DISCLAIMER: The ILO does not take responsibility for content presented on this web portal that is presented in any language other than English, which is the language used for the initial production and peer-review of original content. 1. Gaschromatographic determination of butoxyacetic acid after hydrolysis of conjugated metabolites in urine from workers exposed to 2-butoxyethanol. Environ Health Perspect. Studies on ethylene glycol alkyl ethers and related compounds … 1994;66(4):249-54. doi: 10.1007/BF00454363. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. Pubmed Abstract For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry, 2-Butoxyethanol and 2-Butoxyethanol Acetate, Health Effects of Exposure to Substances and Carcinogens, Community Environmental Health Education Presentations, Case Studies in Environmental Medicine (CSEM), Toxicology Curriculum for Communities Trainer's Manual, Compendium of Papers on MRLs and Health Effects, Agency for Toxic Substances and Disease Registry. EGBE is manufactured by adding n-butyl alcohol and ethylene oxide. Health Hazard Assessments for Noncarcinogenic Effects . 1979 Jan;21(1):29-35 2-BE itself is not commercially produced in Canada. J Occup Health. GENERIC NAME(S): Carbitol (Bulk) ... You may report side effects to Health Canada at 1-866-234-2345. Nausea and … This database provides human health benchmarks for pesticides that may be present in drinking water. Ingestion or skin contact causes headache, nausea, vomiting, dizziness. 1983 May;68(3):405-14 According to 2-Butoxyethanol autoprotection is due to resiliance of newly formed erythrocytes to hemolysis. Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant. -, Nature. | Precautions. In the first study, a group of two men and six rats were exposed simultaneously for 4 hours to an EGBE concentration of 113 ppm in a 1,250 cubic ft room. 4. 1988 Oct;43(1-3):5-21. doi: 10.1016/0378-4274(88)90017-3. NIOSH IDLH: The National Institute for Occupational Safety and Health Immediately Dangerous to Life or Health Ethylene Glycol Monobutyl Ether (Laboratory) Revision Date 15-Dec-2015 Engineering … Ethylene Glycol Monobutyl Ether; Community Right-To-Know Toxic Chemical Release Reporting, 60818-60825 [2015-25674] ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE For Synthesis Safety Data Sheet www.lobachemie.com 03/06/2016 3/8 4.2. In evaluating the hazard that this chemical may pose to man, consideration has been given to likely routes of exposure and its irritant properties. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 4. Arch Toxicol. OBJECTIVES To investigate the effects of ethylene glycol monomethyl ether (EGME) on haematology and reproduction in exposed workers. HHS DEG is a widely used solvent. Acute toxicity: Oral: Harmful if swallowed. Some chromatograms showed that subjects were co-exposed to m-xylene, ethylene glycol monomethyl ether, and ethylene glycol monoethyl ether acetate. Note: Javascript is disabled or is not supported by your browser. 2-Butoxyethanol (bu-tox-zi-eth-an-ol) has many names, including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellosolve, butyl glycol, butyl Oxitol, glycol butyl ether… Ethylene glycol monobutyl ether has also been tested for teratogenldty … Fast, free, expert help 24×7×365 1‑800‑222‑1222. 2-BE … 1984 Aug;57:165-75. doi: 10.1289/ehp.8457165. It can harm the eyes, skin, kidneys, and blood. Clipboard, Search History, and several other advanced features are temporarily unavailable. by Alicia Minns, MD. The level of exposure depends upon the dose, duration, and work being done. The acute and subehronic toxicity of EGEE, EGPE and EGBE was reviewed by C. C. Conaway (Texaco, In view of recent findings with other chemically related glycol ethers, particular attention has been given to possible adverse effects on blood and testicular tissue. Skin Contact Rinse with clear water J Occup Health. METHODS 53 Impregnation workers from two factories that make copper clad laminate with EGME as a solvent were recruited as the exposed group. Epub 2017 Jun 26. ICSC Short-Term Exposure. It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol… Experimental studies on toxicity of ethylene glycol alkyl ethers in Japan. ethylene glycol was prepared by the Institute of Terrestrial Ecology, United Kingdom, based on the report Environmental hazard assessment: Ethylene glycol (Nielsen et al., 1993). Consult a physician. Symptoms/effects after skin contact : Harmful in contact with skin. Office of Pesticide Programs Pesticide Chemical Search. 11.1. It compiles information from several government agencies and organizations. It is liable to form peroxides on exposure to air and light. effects of ethylene glycol monomethyl ether (EGM) have been studied, as has the teratogenicity of ethylene glycol dimethyl ether (EGdM). Toxicol Lett. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. Occupational Exposure to Ethylene Glycol Monobutyl Ether and Ethylene Glycol Monobutyl Ether Acetate. ETHYLENE GLYCOL N-BUTYL ETHER may react with bases, aluminum and oxidizing materials. US NIOSH Target Organs & Routes of Entry It is used as a solvent for lacquers, varnishes, enamels, and epoxy resins. (USCG, 1999) Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, ... 2 Japan Industrial Safety and Health Association. Ethylene glycol monomethyl ether and propylene glycol monomethyl ether: metabolism, disposition, and subchronic inhalation toxicity studies. ETHYLENE GLYCOL ETHERS PANEL TO REMOVE ETHYLENE GLYCOL MONOBUTYL ETHER FROM THE TOXICS RELEASE INVENTORY UNDER SECTION 313 OF THE EMERGENCY PLANNING AND COMMUNITY RIGHT-TO-KNOW ACT OF 1986 Jonathon Busch Director, Ethylene Glycol … Toxicol Appl Pharmacol. Ethylene Glycol Monobutyl Ether 111-76-2 <25 * *The exact percentage (concentration) of composition has been withheld as a trade secret. Tyl RW, Millicovsky G, Dodd DE, Pritts IM, France KA, Fisher LC. 2-Butoxyethanol (2-BE), also known as ethylene glycol monobutyl ether, is a clear liquid with an ether-like odour. Succinctly characterizes the toxicologic and adverse health effects information for a hazardous substance. EPA has denied a petition to remove Ethylene Glycol Monobutyl Ether ... toxicity data for EGBE and concluded that it can reasonably be anticipated to cause serious or irreversible chronic health effects in humans, specifically, liver toxicity and concerns for hematological effects. 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol… Environmental Health Perspectives Vol. NLM Find Lowest Prices. Int J Toxicol. The publication also examines the occupational health risks of exposure to these chemicals and presents criteria for eliminating or minimizing these risks during the manufacture and use of EGBE and EGBEA. In this document, NIOSH recommends occupational exposure limits for ethylene glycol monobutyl ether (EGBE) and its acetate, ethylene glycol monobutyl ether acetate (EGBEA). some . Starek, A., Szymczak, W. and Zapór, L. (2008) Hematological effects of four ethylene glycol monoalkyl ethers in short-term repeated exposure in rats. Likely routes of exposure : Inhalation; Skin and eye contact . Stability No data submitted 3.2. GENERIC NAME(S): Carbitol (Bulk) ... You may report side effects to Health Canada at 1-866-234-2345. This chemical inventory is OSHA's premier one-stop shop for occupational chemical information. 3 Independent Consultant. 111-76-2 - POAOYUHQDCAZBD-UHFFFAOYSA-N - Ethylene glycol mono-n-butyl ether - Similar structures search, synonyms, formulas, resource links, and other chemical information. The RfD is an estimate (with uncertainty … some . Please enable it to take advantage of the complete set of features! 2-butoxyethanol may also be listed as ethylene glycol monobutyl ether, ethylene glycol butyl ether, Butyl Cellosolve, ethylene glycol n-butyl ether, butyl Oxitol, Dowanol EB, glycol butyl ether, Polysolv, and Ektasolve EB. Another group of 121 lamination workers with indirect exposure to EGME was recruited as the control group. Initial adverse health effects caused by ethylene glycol intoxication include central nervous system depression, intoxication, euphoria, stupor, and respiratory depression. DIETHYLEN Glycol M-ETHYL ETHER Liquid. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. ICSC Long-Term Exposure. People who swallowed large amounts of cleaning agents containing 2-butoxyethanol have shown breathing problems, low blood … Bauer P, Weber M, Mur JM, Protois JC, Bollaert PE, Condi A, Larcan A, Lambert H. Intensive Care Med. significantly higher ethylene glycol monobutyl ether concentrations than the control group (geometric mean value: 0.14vs. Google Scholar It is used as a solvent in spray lacquers, enamels, varnishes, and latex paints and as an ingredient in paint thinners and strippers, varnish removers, and herbicides. Abbreviations for 2-butoxyethanol include EGBE and BE [1]. Reregistration Branch 1 Health Effects … ETHYLENE OXIDE Causes reproductive effects . Flammable and/or toxic … Effects of short-term exposure The substance is irritating to the eyes, skin and respiratory tract. Effect of age on the toxicity and metabolism of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol.As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. Where is it found and how is it used? DIPROPYLENE GLYCOL BUTYL ETHER . It is concluded that the available information continues to support the current ACGIH TWA8-TLV of 25 ppm with a STEL of 75 ppm. COVID-19 is an emerging, rapidly evolving situation. ethylene glycol ethers (but not propylene glycol ethers) can damage red blood cells or damage the bone marrow, where blood cells are formed. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. Information on toxicological effects . Where is it found and how is it used? Br J Ind Med. Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant ... 2 Japan Industrial Safety and Health Association. Fact sheet that answers the most frequently asked questions about a contaminant and its health effects. 2-Butoxyethanol … 2-Butoxyethanol acetate is a colorless liquid with a fruity odor. It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol, and butyl Oxitol. Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate … Archives of Toxicology, 82(2), 125-136. Final report on the safety assessment of Triethylene Glycol and PEG-4. NIOSH Pocket Guide to ... in this product - not the product itself - compared to other product formulations. On the other hand, ethylene glycol, ethylene glycol monopropyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monoacetate or ethylene glycol diacetate showed no such an effect. This assessment summarizes available information on Environ Health Perspect. NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC) ... compared to other product formulations. Egme was recruited as the exposed group … ethylene glycol caused very noticeable irritation updates of new results! Of conjugated metabolites in urine from workers exposed to 2-butoxyethanol EGBE belongs to the eyes, skin eye... 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